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Vorasidenib and ivosidenib inhibit mutant forms of isocitrate dehydrogenase (midh) and have shown preliminary clinical activity against midh glioma This is a retrospective case series study in a single cancer care institute. Mutant isocitrate dehydrogenase (idhm) inhibitors represent a novel targeted approach for treating idhm glioma patients, yet their optimal use in clinical practice outside of clinical trials remains undefined
Mutations in the isocitrate dehydrogenase 1 (idh1) gene occur in most lggs (> 70%) Our results support the use of idhi therapy in patients with grade 2 or 3 astrocytoma or oligodendroglioma and highlight limited effectiveness in patients with enhancing disease. Ivosidenib is an inhibitor of mutant idh1 (midh1) under evaluation.
Mellinghoff ik, lu m, wen py, et al
A randomized, perioperative phase 1 trial Based on current evidence, ivosidenib for the treatment of idh mutant glioma has level 3 (low strength/quality) evidence supporting its use.10002,10003,10004,10005 currently available data include phase 1 and retrospective studies and case series.10002,10003,10004,10005 however, based on these data, ivosidenib may have a potential role in. In this large cohort of idhm glioma patients, ivosidenib was well tolerated
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