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Acalabrutinib plus venetoclax, with or without obinutuzumab, significantly improves pfs in untreated cll compared to chemoimmunotherapy This indication is approved under accelerated approval based on overall response rate. Acalabrutinib + venetoclax is taken to decrease symptoms of cll such as enlarged or swollen lymph nodes, enlarged liver or spleen, or symptoms of abnormal bone marrow function, such as frequent infections.
The amplify clinical trial demonstrated that this combination therapy is very effective and well tolerated. Calquence is a bruton tyrosine kinase (btk) inhibitor indicated for the treatment of adult patients with mantle cell lymphoma (mcl) who have received at least one prior therapy This study will address key unanswered questions in frontline chronic lymphocytic leukemia/small lymphocytic lymphoma therapy by investigating the optimal duration of finite treatment and identifying the optimal venetoclax doublet regimen.
Developers have submitted a supplemental new drug application for a fixed duration, oral combination of venetoclax (venclexta) in combination with acalabrutinib (calquence) in patients with previously untreated chronic lymphocytic leukemia (cll), according to a news release from abbvie
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