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In this review, we focus on a group of mobile genetic elements designated pathogenicity islands (pai) They are incorporated in the genome of pathogenic organisms, but are usually absent from those nonpathogenic organisms of the same or closely related species. These elements play a pivotal role in the virulence of bacterial pathogens of humans and are also essential for virulence in pathogens of animals and plants.
Pathogenicity islands (pais), as termed in 1990, are a distinct class of genomic islands acquired by microorganisms through horizontal gene transfer Pathogenicity islands (pais) are a distinct class of genomic islands acquired by microorganisms through horizontal gene transfer [1][2] pathogenicity islands are found in both animal and plant pathogens
These islands often carry genes involved in pathogenicity, allowing the bacteria to cause disease in their host organisms
There are several pathogenicity islands, each associated with specific functions or mechanisms. Many of the virulence genes, which encodes virulence factors, are clustered together on the bacterial chromosomes A significant fraction of virulence gene clusters are located on mobile genetic elements, known as the “pathogenicity islands” (pais) [1] Thus a pai allows bacteria to induce diseases.
Pais encode genes which contribute to the virulence of pathogenic bacteria
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