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Deutetrabenazine reversibly depletes the levels of monoamines, such as dopamine, serotonin, norepinephrine, and histamine, from nerve terminals via its active metabolites. Austedo works to lower neurotransmitter levels, which are chemicals in the body that are communicated between cells. Deutetrabenazine, sold under the brand name austedo, is a vesicular monoamine transporter 2 inhibitor which is used for the treatment of chorea associated with huntington's disease and tardive dyskinesia.
Mechanism of action the drug functions by binding to vmat2, which normally packages monoamines like dopamine into vesicles for release at nerve terminals How does austedo work (mechanism of action) By inhibiting this transporter, deutetrabenazine decreases the uptake of monoamines into synaptic vesicles, resulting in less dopamine being available for release into the synapse.
Austedo's drug class is a vmat2 inhibitor (vesicular monoamine transporter 2 inhibitor)
What is tardive dyskinesia (td) and chorea associated with huntington’s disease Deutetrabenazine (austedo) can increase the risk of depression and suicidal thoughts and behavior (suicidality) in patients with huntington’s disease Anyone considering the use of deutetrabenazine (austedo) must balance the risks of depression and suicidality with the clinical need for treatment of chorea. Deutetrabenazine, also known by its brand name austedo, is a medication primarily used to treat involuntary movements (chorea) associated with huntington's disease and tardive dyskinesia
Understanding the mechanism of deutetrabenazine requires an exploration of its pharmacodynamics, pharmacokinetics, and the specific pathways it targets within the nervous system Highlights of prescribing information these highlights do not include all the information needed to use austedo xr or austedo safely and effectively See full prescribing information for austedo xr and austedo
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