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You may experience short periods where compuspections is not available At the phagocytic synapse, sirpa inhibited integrin activation to limit macrophage spreading across the surface of the engulfment target. We are working to correct these issues quickly

Thank you for your patience. We found that cd47 ligation altered sirpa localization, positioning sirpa for activation at the phagocytic synapse Sirpα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein cd47 also called the don't eat me signal

This interaction negatively controls effector function of innate immune cells such as host cell phagocytosis.

Complete information for sirpa gene (protein coding), signal regulatory protein alpha, including Function, proteins, disorders, pathways, orthologs, and expression. Notably, sirpa−/− mice were more resistant to. Mechanistically, sirpa is regulated by its pseudogene, sirpap1

Ubiquitous expression in brain (rpkm 71.2), appendix (rpkm 27.2) and 23 other tissues

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