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INT-777（S-EMCA）是有效的 TGR5 激动剂，EC50 为 0.82 μM。 INT-777（S-EMCA）在大鼠蛛网膜下腔出血后通过 TGR3/cAMP/PKA 信号通路抑制 NLRP5-ASC 炎症小体介导的神经炎症。 丁香通为您提供上海莼试TGR5激动剂 (INT777) 价格等详细信息，产品供应商为上海莼试生物技术有限公司，产品类别为试剂-细胞生物学检测-细胞凋亡，货号是CS-X12551。 View INT-777 Datasheet. INT-777 (S-EMCA) 是 TGR5 (GPCR19) 的有效选择性激动剂，对 TGR5、TGR5 (N76A) 和 TGR5 (Y89F) 的 EC50 分别为 0.18 μM、3.9 μM 和 1.45 μM。 Quality confirmed by NMR & HPLC. See customer reviews, validations & product citations.
INT-777: 一种TGR5激动剂药物，由Intercept Pharmaceuticals, Inc. (Intercept Pharmaceuticals, Inc.)公司最早进行研发，目前全球最高研发状态为无进展，作用机制: TGR5激动剂 (G蛋白偶联胆汁酸受体1激动剂)，治疗领域: 内分泌与代谢疾病。
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