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In two studies, semaglutide failed to slow decline in thousands of people with early stages of alzheimer's disease. The studies were a setback for the optimistic view that semaglutide and other drugs used in obesity and diabetes treatment could help prevent a number of brain diseases. An oral version of semaglutide, the active ingredient in blockbuster drugs ozempic and wegovy, failed to slow the progression of alzheimer’s disease in closely watched trials, drugmaker novo.
In two phase 3 trials, researchers tested an oral form of semaglutide in more than 3,800 adults with alzheimer’s who were already receiving standard care Novo nordisk announced monday that in two closely watched studies, an oral version of semaglutide — the active ingredient in weight loss drugs — failed to help slow the progression of. While the drug was safe and improved some biological markers linked to the disease, it did not slow memory or cognitive decline compared to a placebo.
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