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Lrrk2 (leucine rich repeat kinase 2) is a protein coding gene Tuberin interacts with hamartin to form the tsc protein complex which functions in the control of cell growth. Diseases associated with lrrk2 include parkinson disease 8, autosomal dominant and parkinson's disease.
This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. This gene is a tumor suppressor gene that encodes the growth inhibitory protein tuberin Wt1 is a tumor suppressor gene associated with the development of wilms' tumor, from which it was named
Mutations in exon 7 and 9 of wt1 have been recurrently identified in acute myeloid leukemia and associated with poorer prognosis and chemotherapy resistance.
Function, proteins, disorders, pathways, orthologs, and expression. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. This gene encodes a transcription factor containing a pou homeodomain that plays a key role in embryonic development and stem cell pluripotency
Aberrant expression of this gene in adult tissues is associated with tumorigenesis. Complete information for nmnat2 gene (protein coding), nicotinamide nucleotide adenylyltransferase 2, including Dna polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in dna replication and repair.
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