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The overall incidence of aplastic anemia in the study area was 2.34 cases per million population per year, and the mortality at 2 years was nearly one death per million per year. As the data available on aa varies substantially worldwide, a multicenter, ambispective, observational study was carried out between 2010 and 2019 to assess the incidence, clinical management and survival of aa at seven spanish hospitals. Incidence is up to five times higher in asia than in europe [1, 3, 4].
Our systematic literature review (slr) of costs of illness of severe aa (saa) globally describes the economic implications of the disease. Multivariate analysis showed that age ≥40 years The incidence is 2 to 3 per million per year in europe, but higher in east asia
[7] there is a bimodal distribution peaking at 10 to 25 years of age and above 60 years of age, and there is no difference between male and female gender.
The incidence in europe per year ranges from 1 to 3.5/million people [1, 2], and the prevalence is about 16/million people [3] While new treatment options have emerged, most patients still experience reduced quality of life (qol) [4]. Diagnostic criteria to distinguish hypocellular acute myeloid leukemia from hypocellular myelodysplastic syndromes and aplastic anemia Recommendations for a standardized approach [2009]
Its global incidence rate ranges from 0.7 to 7.4 cases per million inhabitants per year, with higher rates in asia compared to europe and the united states Trisomy 8 is one of the most common cytogenetic abnormalities detected in aplastic anemia However, this finding is not specific, as it can occur also in other myeloid neoplasms and it has been described in nonneoplastic conditions. 57 confirmed cases, with an overall incidence of 2.35 cases per million inhabitants per year
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